Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis

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Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis

BACKGROUND Interstitial cystitis/painful bladder syndrome (IC/PBS) is a bladder disease that causes debilitating pelvic pain of unknown origin, and IC/PBS symptoms correlate with elevated bladder lamina propria mast cell counts. Similar to IC/PBS patients, pseudorabies virus (PRV) infection in mice induces a neurogenic cystitis associated with bladder lamina propria mast cell accumulation and p...

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Interstitial cystitis: a chronic pelvic pain syndrome.

Interstitial cystitis, an enigmatic chronic pelvic pain syndrome that occurs primarily in women, is much more common than originally believed. Its etiology is unknown, its evaluation and diagnosis remain controversial, and its treatment is largely empiric. Recent basic and clinical research is unlocking some of the mystery surrounding this clinical syndrome. Diagnostic awareness, willingness to...

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From interstitial cystitis to chronic pelvic pain

There are still many things to be found out about interstitial cystitis/painful bladder syndrome (IC/PBS) because the pathological processes underlying the condition are not yet elucidated, biological markers of the condition are not yet available, and the type and severity of symptoms can vary, so, clearly defining the condition is not yet possible. For example, it is not clearly understood wh...

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Interstitial Cystitis in Persistent Posthysterectomy Chronic Pelvic Pain

OBJECTIVES Hysterectomies may be performed unnecessarily in women with chronic pelvic pain if the diagnosis of interstitial cystitis is not considered. The objectives of this study were to investigate the prevalence of interstitial cystitis in patients with posthysterectomy chronic pelvic pain and to evaluate the efficacy of various therapies for interstitial cystitis. METHODS A study was per...

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Chronic Pelvic Pain: the Occurrence of Interstitial Cystitis in a Gynecological Population

OBJECTIVE The objective of this study was to determine what relationship exists between interstitial cystitis and chronic pelvic pain in patients. METHODS A prospective study of 35 women with a complaint of chronic pelvic pain was performed between August 2002 and September 2003. These patients underwent a workup to exclude other causes of pelvic pain and underwent a laparoscopy and a cystosc...

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ژورنال

عنوان ژورنال: BMC Urology

سال: 2009

ISSN: 1471-2490

DOI: 10.1186/1471-2490-9-16